The content within this chapter is included in our Instructions for Use.

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Host System Configuration

The LumiNE US software is a cloud-based application that can be used via a web browser with internet connection and/or a wireless stereoscopic Head-Mounted Display.

 

Supported web browsers and operating system include:

• Google Chrome (version 90.0.4430 and later) running on Windows 10 and later

• Microsoft Edge (version 83.0.0 and later) running on Windows 10 and later

• Mozilla Firefox (version 78.10 and later) running on Windows 10 and later

 

Supported wireless stereoscopic Head-Mounted Displays include:

• Microsoft HoloLens 2nd generation

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Minimum network requirements (for the Multiplayer feature):

• Minimum download speed of 6.12 Mbps, minimum upload speed of 1.05 Mbps and a maximum network ping of 99 ms (Multiplayer feature)

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User Configuration

Only users with accounts provided by Augmedit can use the LumiNE US software. User can access the LumiNE US software with a personal login.

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Segmentation Functionalities

For the conversion of 2D image data into 3D structures of the head, the following functionalities may be used:

• MRI T1 Segmentation Function (T1cSF): This function transforms contrast enhanced T1-weighted MR images (MRI-T1) of the head into 3D models of the skin, brain, and ventricles.  The LumiNE US T1cSF can thereby be used for tumor segmentation only in case of a single intracranial contrast enhancing tumor, diagnosed by a neuroradiologist or a neurosurgeon, with a minimal volume of 2.0 cc (0.1 in3) and a minimal diameter in any direction of 15 mm (0.6 inch), and a maximum volume of 100cc (6.1 in3)  and a maximal diameter in any direction of 75 mm (3.0 inch). Results can be evaluated in every step of the workflow using outline functions on medical imaging. Users can adjust and remove segmentation results. The assigned labels can be renamed by the user.

• CT segmentation Function: Users can segment CT images of the head manually by adjusting thresholds using sliders and select and clip specific parts. Modifications can be visualized directly in the 3D viewer and the selected parts can be transformed into a 3D model when satisfied.

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Input Image Requirements for semi-automatic MRI segmentation (T1cSF)

The following requirements apply for the MRI T1 Segmentation Function (T1cSF):

• Image type: T1 MRI with contrast of the cranium from the vertex to at least the foramen magnum level and maximally to the C2 level.

• Slices per series:  Minimum 100 slices per series with a maximum slice thickness and slice interval of 2 mm.

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Input Image Requirements for manual CT segmentation 

The following requirements apply for the manual CT segmentation function:

• Image type: CT images of the cranium.

• Slices per series:  Minimum 104 slices per series with a maximum slice thickness and slice interval of 2.5 mm.

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The visualization of the image data and the output representations are based on the data quality and resolution of the original image data series. In case of poor image contrast, resolution, scan artifacts (such as patient movement) or other image related defects or inaccuracies, this can lead to inaccurate results.

 

Input Image Limitations:

The LumiNE US software is not compatible with: ​

• Series with more than 2048 slices

• Scans in NifTi format

• Multiframe DICOM

• Modalities other than MR or CT (such as PET, DTI, PET etc.),

• DICOM series which contains multiple subseries 

• Scans with missing slices

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Planning Tools

Marking of 3D models can be made in the wireless stereoscopic Head-Mounted Display for pre-operative planning, a detailed description and step-by-step instructions are available  in this User Guide.

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Use Environment

In case the LumiNE US software is used in combination with the wireless stereoscopic Head-Mounted Display, stable light levels are required for optimal performance. The wireless stereoscopic Head-Mounted Display can be used in in dark environment (20 Lux), ambient lightning environment (600 Lux, e.g. outpatient clinic) and operation theater (600 Lux). LumiNE US software can be used in  the following environments with the following features: